Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Acute kidney injury
ADR ID BADD_A06560
ADR Hierarchy
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.03      Renal failure and impairment
20.01.03.016      Acute kidney injury
Description A disorder characterized by the acute loss of renal function (within 2 weeks) and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction). [CTCAE] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. | Conditions in which the function of KIDNEYS deteriorates suddenly in a matter of days or even hours. It is characterized by the sudden drop in GLOMERULAR FILTRATION RATE. [MeSH]
MedDRA Code 10069339
MeSH ID D058186; D058186; D058186
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute kidney failure | Acute on chronic renal failure | Acute renal failure | Acute renal failure following labor and delivery | Acute renal failure following labor and delivery, postpartum condition or complication | Acute renal failure following labor and delivery, unspecified as to episode of care | Acute renal failure following labour and delivery | Acute renal failure with delivery, with mention of postpartum complication | Acute renal failure with lesion of renal cortical necrosis | Acute renal failure with lesion of renal medullary (papillary) necrosis | Acute renal failure with lesion of tubular necrosis | Acute renal failure with other specified pathological lesion in kidney | Acute renal failure, unspecified | ARF | Failure kidney acute | Kidney failure acute | Renal failure acute | Renal failure acute hypotensive | Renal failure acute ischaemic | Renal failure acute ischemic | Renal failure acute on chronic | Renal failure acute uratic | Renal shutdown acute | Shutdown renal | Acute renal insufficiency | Rhabdomyolysis-induced renal failure | Acute oliguric renal failure | Acute kidney injury | Acute Kidney Injury | Acute Kidney Injuries | Kidney Injuries, Acute | Kidney Injury, Acute | Acute Renal Injury | Acute Renal Injuries | Renal Injuries, Acute | Renal Injury, Acute | Renal Insufficiency, Acute | Acute Renal Insufficiencies | Renal Insufficiencies, Acute | Acute Renal Insufficiency | Kidney Insufficiency, Acute | Acute Kidney Insufficiencies | Kidney Insufficiencies, Acute | Acute Kidney Insufficiency | Kidney Failure, Acute | Acute Kidney Failures | Kidney Failures, Acute | Acute Renal Failure | Acute Renal Failures | Renal Failures, Acute | Renal Failure, Acute | Acute Kidney Failure
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Nuclear receptor coactivator 1Q15788Not Available
Peroxisomal acyl-coenzyme A oxidase 1Q15067Not Available
Retinoic acid receptor RXR-alphaP19793T13726
UromodulinP07911Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00668Digoxin0.015697%
BADD_D00673Dihydrogen phosphate--
BADD_D00674Diltiazem0.000830%
BADD_D00680Dimethyl fumarate--
BADD_D00686Diphenhydramine0.003537%
BADD_D00699Docetaxel--
BADD_D00701Dofetilide0.001669%
BADD_D00702Dolasetron--
BADD_D00706Donepezil0.002289%
BADD_D00708Dopamine0.000145%
BADD_D00718Doxazosin0.001454%
BADD_D00720Doxepin0.003625%
BADD_D00723Doxorubicin0.007460%
BADD_D00725Doxycycline0.000105%
BADD_D00730Dronedarone0.008980%
BADD_D00732Droxidopa--
BADD_D00734Duloxetine--
BADD_D00736Dutasteride0.002608%
BADD_D00749Efavirenz--
BADD_D00759Eltrombopag--
BADD_D00765Empagliflozin0.023956%
BADD_D00766Emtricitabine--
BADD_D00774Entecavir0.052437%
BADD_D00775Enzalutamide--
BADD_D00782Epinephrine--
BADD_D00784Epirubicin--
BADD_D00786Eplerenone0.374302%
BADD_D00788Epoprostenol--
BADD_D00794Ergocalciferol0.000406%
BADD_D00798Eribulin--
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